General Anesthesia and Systemic Hyperosmolality Modulate Lumbar Intrathecal Drug Distribution in Female Rats
Anesthesia modulates the distribution of intrathecally administered drugs at the spinal and intracranial levels. Systemic HTS increased the intracranial availability of spinally administered drugs during ketamine-dexmedetomidine and prolonged the CNS availability of spinal drugs in the awake state. These interventions should be taken to clinical trials to improve efficacy and to reduce side effects of spinally administered drugs.
Authors
- J. Arturo García‐Horsman (ORCID: https://orcid.org/0000-0002-9680-717X)
- Tomi Rantamäki (ORCID: https://orcid.org/0000-0002-0052-1434)
- Tuomas O. Lilius (ORCID: https://orcid.org/0000-0002-8361-3683)
- Jenni E. Anttila (ORCID: https://orcid.org/0000-0001-6565-2323)
- Mirkka P. Sarparanta (ORCID: https://orcid.org/0000-0002-2956-4366)
- Terhi J. Lohela (ORCID: https://orcid.org/0000-0002-6596-1780)
- Maiken Nedergaard (ORCID: https://orcid.org/0000-0001-6502-6031)
- Marko Rosenholm (ORCID: https://orcid.org/0000-0002-5437-8282)
- Niklas Daniel Åke Persson (ORCID: https://orcid.org/0000-0003-3755-4579)
- Jyrki P. Mäkelä (ORCID: https://orcid.org/0000-0003-1252-4728)
- Mirva J Peltoniemi
- Sonja C. Jalonen
Institutions
- University of Copenhagen (DK)
- University of Helsinki (FI)
- Helsinki University Hospital (FI)
- University of Rochester Medical Center (US)
Publication Details
- Journal
- Anesthesiology
- Published
- 2025-10-09
- DOI
- https://doi.org/10.1097/aln.0000000000005794
- Citations
- 1
- Primary Topic
- Cerebrospinal fluid and hydrocephalus
- Type
- article
- Field-Weighted Citation Impact
- 0.91
Funders
- Helsingin Yliopisto
- Suomen Lääketieteen Säätiö
- Lundbeckfonden
- Novo Nordisk
- Emil Aaltosen Säätiö
- Sigrid Juséliuksen Säätiö
- Faculty of Health and Medical Sciences, University of Western Australia
- H. Lundbeck A/S
- Det Sundhedsvidenskabelige Fakultet, Københavns Universitet