A Hybrid Lesion of Central Giant Cell Granuloma and Juvenile Trabecular Ossifying Fibroma: A Case Report of an Extremely Rare Combined Lesion in the Maxilla

Abstract Juvenile trabecular ossifying fibroma (JTOF) is a rare variant of ossifying fibroma, a benign fibro-osseous lesion. This entity is characterized by aggressive clinical behavior, predominantly affecting young individuals aged 8–12 years. A slight male predominance has been observed, and the lesion demonstrates a marked propensity for recurrence. Central giant cell granuloma (CGCG) is classified by the World Health Organization as a benign nonodontogenic lesion of the jaw, with unknown etiology. It is an uncommon, benign but aggressive osteolytic neoplasm of the craniomaxillofacial region. We report a case of a 6-year-old female child who presented with a painless, slow-growing swelling over her left cheek for 3 months. A large expansile lesion of neoplastic etiology of the left maxilla was suspected clinically and on radiological examination. A thorough histological examination revealed it to be a hybrid lesion of CGCG with JTOF, which in combination is extremely rare.