TGF-β–Smad2/3 signaling in high-altitude pulmonary hypertension in rats: Role and mechanisms via macrophage M2 polarization
The TGF-β-Smad2/Smad3 pathway promotes macrophage M2 polarization, driving HAPH progression through anti-inflammatory cytokine release. Inhibiting this pathway reduces M2 polarization and alleviates HAPH in rats, highlighting its therapeutic potential.
Authors
- Xiaoling Su (ORCID: https://orcid.org/0000-0002-0899-2134)
- Q Zhang
- Wende Ma
- Yumei Ma (ORCID: https://orcid.org/0000-0003-0367-090X)
- Y. Bai (ORCID: https://orcid.org/0000-0002-9757-7660)
- Cen Guo (ORCID: https://orcid.org/0000-0001-6850-1045)
Institutions
- Qinghai University (CN)
- Qinghai Provincial Peoples Hospital (CN)
- Experimental Center of Forestry in North China (CN)
Publication Details
- Journal
- Open Medicine
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1515/med-2025-1279
- Citations
- 1
- Primary Topic
- Pulmonary Hypertension Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.52