SPP1 in notochord cells modulates intervertebral disc degeneration through CD44 recognition by macrophages based on single-cell transcriptome analysis
This study provides insights into IVDD mechanisms, focusing on the role of the SPP1-CD44 pathway in disc degeneration. We suggest that targeting this pathway may offer potential therapeutic strategies for degenerative spinal diseases.
Authors
- Renjie Zhang (ORCID: https://orcid.org/0000-0002-7203-5769)
- Qiuwei Li (ORCID: https://orcid.org/0000-0002-2306-6649)
- Chenhao Zhao (ORCID: https://orcid.org/0000-0001-7256-6714)
- Cailiang Shen (ORCID: https://orcid.org/0000-0001-8778-9398)
- Ping Jin (ORCID: https://orcid.org/0000-0001-7655-1077)
Institutions
- Anhui Medical University (CN)
- First Affiliated Hospital of Anhui Medical University (CN)
Publication Details
- Journal
- International Journal of Surgery
- Published
- 2025-10-07
- DOI
- https://doi.org/10.1097/js9.0000000000003454
- Citations
- 1
- Primary Topic
- Spine and Intervertebral Disc Pathology
- Type
- article
- Field-Weighted Citation Impact
- 1.47