Multi-omics dissection of high TWAS-active endothelial pathogenesis in pulmonary arterial hypertension: bridging single-cell heterogeneity, machine learning-driven biomarkers, and developmental reprogramming
This study elucidates endothelial cell heterogeneity in PAH and establishes the central role of HTS cells in disease progression, cellular crosstalk, and developmental reprogramming. Our findings bridge the gap between GWAS and scRNA-seq methodologies and provide a transformative framework for understanding PAH mechanisms.
Authors
- Ming Yang (ORCID: https://orcid.org/0000-0002-6367-8199)
- Zerong Li (ORCID: https://orcid.org/0000-0003-1712-7158)
- Zhongkai Wu (ORCID: https://orcid.org/0000-0003-1184-1182)
- Bin Fan (ORCID: https://orcid.org/0009-0005-3390-2654)
- Lin Zhou (ORCID: https://orcid.org/0000-0001-7973-9403)
- Siming Yu (ORCID: https://orcid.org/0000-0002-3857-876X)
- Fang Qiu (ORCID: https://orcid.org/0000-0003-4966-2032)
- Jinping Wang (ORCID: https://orcid.org/0000-0003-4325-9939)
- Huayang Li (ORCID: https://orcid.org/0000-0003-4898-2501)
- Wenmei Qiao
Institutions
- Sun Yat-sen University (CN)
- Southern University of Science and Technology (CN)
- Shantou University (CN)
- Shantou University Medical College (CN)
- Peking University Shenzhen Hospital (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- Shenzhen Second People's Hospital (CN)
Publication Details
- Journal
- International Journal of Surgery
- Published
- 2025-10-09
- DOI
- https://doi.org/10.1097/js9.0000000000003601
- Citations
- 1
- Primary Topic
- Pulmonary Hypertension Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.52