Detection of pleiotropic genetic factors and critical brain cell types linking insomnia with psychiatric disorders
Our findings reveal extensive shared genetic architecture between insomnia and psychiatric disorders, converging on cortical GABA-glutamate circuitry dysfunction. These results identify potential therapeutic targets for comorbid conditions and demonstrate how integrating genetic epidemiology with cellular neuroscience can elucidate transdiagnostic mechanisms underlying neuropsychiatric comorbidity, informing precision medicine approaches.
Authors
- Yuanchao Sun
- Xiangzhong Zhao (ORCID: https://orcid.org/0000-0002-8064-066X)
- Mingming Niu
- Wei Shi (ORCID: https://orcid.org/0000-0002-2087-2223)
- Yuan Wen (ORCID: https://orcid.org/0000-0002-9612-7975)
- Chengwen Gao (ORCID: https://orcid.org/0000-0001-7694-8023)
- Lin Wang (ORCID: https://orcid.org/0000-0002-3889-5714)
- Zhiqiang Li (ORCID: https://orcid.org/0000-0002-0174-9254)
- Xiangyu Li (ORCID: https://orcid.org/0000-0002-5260-2308)
- Junting Liu (ORCID: https://orcid.org/0009-0004-1831-9527)
- Baiqiang Xue (ORCID: https://orcid.org/0009-0000-8217-604X)
- Haiyan Song (ORCID: https://orcid.org/0000-0002-8540-0227)
- Yonghe Ding
- Qian Zhang
- Chuanhong Wu
- Baokun Wang
- Lixia Peng
Institutions
- Qingdao University (CN)
- Shanghai Jiao Tong University (CN)
- Institute for Breathing and Sleep (AU)
- Ministry of Education (KR)
- Affiliated Hospital of Qingdao University (CN)
Publication Details
- Journal
- SLEEP
- Published
- 2025-10-08
- DOI
- https://doi.org/10.1093/sleep/zsaf317
- Citations
- 2
- Primary Topic
- Child Nutrition and Feeding Issues
- Type
- article
- Field-Weighted Citation Impact
- 2.94