Matcha intake enhances systemic oxidative stress resistance and activates detoxification pathways in <i>Drosophila melanogaster</i>

Matcha, a Japanese powdered green tea, enhances Drosophila resistance to oxidative stress. Transcriptome analysis shows activation of detoxification and antioxidant pathways, likely driven by caffeine-catechin synergy. Unlike green tea catechins, matcha did not extend lifespan under high-protein diets, underscoring complex physiological effects and validating Drosophila as a nutrigenomic model.