Therapeutic Response of Trichloroacetic Acid Peel in Patients With Acanthosis Nigricans

Background: Acanthosis nigricans (AN) is a pigmentary disorder with various treatment options available for management. Topical alpha-hydroxy acids and keratolytic agents improve appearance by reducing hyperkeratosis. Aims: The aim of the study is to evaluate the safety and efficacy of 15% trichloroacetic acid (TCA) in patients with acanthosis nigricans. Methods: Ten consecutive patients with AN on the neck received four sessions of TCA peel (15%) at 2-week intervals after taking informed consent. Response to treatment was evaluated using a grading system, i.e., minimal, moderate, good, and excellent improvement. Adverse effects were evaluated at every visit. Results: Out of ten patients, three showed minimal improvement, four showed moderate improvement, and two showed good improvement in AN after four sessions of TCA peel. Three out of ten patients showed mild desquamation after the procedure, which improved within 3–4 days. Conclusion: TCA peel (15%) is an effective and safe treatment for the management of AN.