T-cell receptor sequencing for detection of Epstein-Barr and cytomegalovirus-specific immune responses in glioma patients: An exploratory study
Interrogation of blood samples for CDR3 sequences describing the human TCR repertoire offers a novel tool for investigating anti-viral immune response in glioma. More robust immunity to herpesviruses could result in cross-reactive, primed cyto-toxic immune responses that potentially suppress development of more aggressive tumors.
Authors
- Anna E. Coghill (ORCID: https://orcid.org/0000-0001-7142-7499)
- Nathan Van Bibber
- Kathleen M. Egan (ORCID: https://orcid.org/0000-0001-8772-6979)
- George Blanck (ORCID: https://orcid.org/0000-0003-1664-0996)
- Sean Yoder (ORCID: https://orcid.org/0000-0002-3120-3279)
- Sepideh Mokhtari (ORCID: https://orcid.org/0000-0001-5755-1469)
- Sugriva Forsyth
Institutions
- University of South Florida (US)
- Moffitt Cancer Center (US)
Publication Details
- Journal
- Neuro-Oncology Advances
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1093/noajnl/vdaf216
- Primary Topic
- Cytomegalovirus and herpesvirus research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Moffitt Cancer Center
- National Cancer Institute