Screening for Tumor Microtube–Targeting Drugs Identifies PKC Modulators as Multipotent Inhibitors of Glioblastoma Progression
Cancers can hijack neural properties to grow, disseminate, and to resist therapies, but effective drug development pipelines against these features are missing. Here, we establish a compound screening approach that allowed the identification of PKC modulators that target cancer cell-intrinsic neurodevelopmental mechanisms, suggesting a new class of neuroscience-instructed cancer therapeutics.
Authors
- Matthia A. Karreman (ORCID: https://orcid.org/0000-0003-0074-5945)
- Frank Winkler (ORCID: https://orcid.org/0000-0003-4892-6104)
- Gina Cebulla
- Pino Bordignon (ORCID: https://orcid.org/0000-0002-3157-8695)
- Dirk C. Hoffmann (ORCID: https://orcid.org/0000-0003-1370-1933)
- Anna Kreshuk (ORCID: https://orcid.org/0000-0003-1334-6388)
- Denise Reibold
- Nils Hebach (ORCID: https://orcid.org/0000-0003-1921-3244)
- Susann Wendler (ORCID: https://orcid.org/0000-0003-0579-5001)
- Ammar Jabali (ORCID: https://orcid.org/0000-0002-2772-8531)
- Jill Reckless
- Andreas E. Moor (ORCID: https://orcid.org/0000-0001-8715-8449)
- Tim Holland‐Letz (ORCID: https://orcid.org/0000-0003-0348-8163)
- Nigel G. Ramsden
- David Hausmann (ORCID: https://orcid.org/0000-0002-0571-4710)
- Matthias Osswald (ORCID: https://orcid.org/0000-0003-3760-4046)
- Rajiv K. Khajuria
- David J. Grainger (ORCID: https://orcid.org/0000-0002-3211-2045)
- Philipp Koch (ORCID: https://orcid.org/0000-0003-3713-8786)
- Sandra Horschitz (ORCID: https://orcid.org/0000-0001-9295-5493)
- Cathrin Löb (ORCID: https://orcid.org/0000-0003-0621-4934)
- Pascal Lehnert
- Wolfgang Wick (ORCID: https://orcid.org/0000-0002-6171-634X)
- Erik Jung (ORCID: https://orcid.org/0000-0002-5016-8202)
- Chanté D. Mayer (ORCID: https://orcid.org/0000-0001-7885-6798)
- Ling Hai (ORCID: https://orcid.org/0000-0001-8719-2727)
- Miriam Ratliff (ORCID: https://orcid.org/0000-0002-9464-6544)
- Tobias Keßler (ORCID: https://orcid.org/0000-0001-8350-7074)
- Daniel Domínguez Azorín (ORCID: https://orcid.org/0000-0002-0002-4307)
- Sophie Heuer (ORCID: https://orcid.org/0000-0002-3373-5295)
Institutions
- German Cancer Research Center (DE)
- Heidelberg University (DE)
- University Hospital Heidelberg (DE)
- ETH Zurich (CH)
- Praxis (United Kingdom) (GB)
- Central Institute of Mental Health (DE)
- National Center for Tumor Diseases (DE)
- Hexcel (United Kingdom) (GB)
- Centro Medico Nacional Siglo XXI (MX)
- The Taiwanese Osteoporosis Association (TW)
- Medication Management (United States) (US)
- Dexcel Pharma (United Kingdom) (GB)
- European Molecular Biology Laboratory (DE)
- Hertie Institute for Clinical Brain Research (DE)
- Moximed (United States) (US)
- European Molecular Biology Laboratory (DE)
- University Medical Centre Mannheim (DE)
Publication Details
- Journal
- Cancer Discovery
- Published
- 2025-10-09
- DOI
- https://doi.org/10.1158/2159-8290.cd-24-0414
- Citations
- 1
- Primary Topic
- Microtubule and mitosis dynamics
- Type
- article
- Field-Weighted Citation Impact
- 1.15