A practical guide to simulation for an adaptive trial design with a single interim analysis
When using simulation to design an adaptive trial, the simulations must be tailored to the unique design requirements of the trial at hand. This tutorial provides a foundational framework designed to make the simulation process more accessible to both statisticians and clinicians.
Authors
- Michael Dymock (ORCID: https://orcid.org/0000-0003-4881-2860)
- Kaushala S. Jayawardana (ORCID: https://orcid.org/0000-0002-7500-9814)
- Robert K. Mahar (ORCID: https://orcid.org/0000-0002-3643-923X)
- Julie Marsh (ORCID: https://orcid.org/0000-0001-8984-6907)
- Katherine J. Lee (ORCID: https://orcid.org/0000-0002-8334-0291)
Institutions
- The University of Melbourne (AU)
- The Kids Research Institute Australia (AU)
- The University of Western Australia (AU)
- Yahoo (Spain) (ES)
- Murdoch Children's Research Institute (AU)
- Melbourne Health (AU)
Publication Details
- Journal
- Trials
- Published
- 2025-10-09
- DOI
- https://doi.org/10.1186/s13063-025-09100-5
- Primary Topic
- Statistical Methods in Clinical Trials
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Children’s Hospital of Wisconsin Research Institute
- Murdoch Children's Research Institute
- State Government of Victoria
- Medical Research Council
- National Health and Medical Research Council