Cortical surface area as a stronger mediator of the waist-to-height ratio and cognitive impairment link in patients with first-episode schizophrenia compared to body mass index and waist-hip ratio
CSA, particularly in the right inferior parietal gyrus, mediates the relationship between obesity metrics and cognitive function. WHtR may be a more reliable marker than BMI or WHR for assessing abdominal obesity's impact on cognition, offering insights into the mechanisms of cognitive deficits in schizophrenia.
Authors
- Zhiren Wang (ORCID: https://orcid.org/0000-0002-2016-0517)
- Yanli Li (ORCID: https://orcid.org/0000-0002-2936-0339)
- Ting Xie (ORCID: https://orcid.org/0000-0002-6648-7697)
- Yunlong Tan (ORCID: https://orcid.org/0000-0002-3522-3912)
- Mengzhuang Gou (ORCID: https://orcid.org/0000-0001-7341-5387)
- Yanfang Zhou (ORCID: https://orcid.org/0000-0001-8561-456X)
- Jinghui Tong (ORCID: https://orcid.org/0009-0009-7480-0856)
- Ting Yu (ORCID: https://orcid.org/0000-0001-5858-5177)
- Yimin Cui (ORCID: https://orcid.org/0000-0002-4186-1005)
- Ping Zhang (ORCID: https://orcid.org/0000-0001-9163-6191)
- Song Chen (ORCID: https://orcid.org/0000-0001-7185-0123)
- Lin Chen (ORCID: https://orcid.org/0000-0003-0108-4309)
- Xingguang Luο (ORCID: https://orcid.org/0000-0003-3585-042X)
- Junchao Huang (ORCID: https://orcid.org/0000-0003-1066-3206)
- Yi Yin (ORCID: https://orcid.org/0000-0002-8386-5573)
- Shujuan Pan (ORCID: https://orcid.org/0000-0001-5338-4771)
Institutions
- Peking University (CN)
- Yale University (US)
- Peking University First Hospital (CN)
- Beijing HuiLongGuan Hospital (CN)
Publication Details
- Journal
- BMC Psychiatry
- Published
- 2025-10-09
- DOI
- https://doi.org/10.1186/s12888-025-07458-z
- Primary Topic
- Schizophrenia research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China