Transcriptomic analysis demonstrates moderators of muscle quality are altered in age-related sarcopenic obesity
Taken together, our findings reveal specific pathways of dysregulation in SO skeletal muscle, offering molecular insights that enhance our understanding of the underlying mechanisms contributing to impaired muscle function in this condition. Further exploration of these dysregulations is critical to identifying therapeutic treatments targeting the source of muscle functional impairment in SO.
Authors
- Nicholas P. Greene (ORCID: https://orcid.org/0000-0001-9621-2005)
- Eleanor R. Schrems
- Tyrone A. Washington (ORCID: https://orcid.org/0000-0002-1919-5907)
- Kevin A. Murach (ORCID: https://orcid.org/0000-0003-2783-7137)
- Ana Regina Cabrera (ORCID: https://orcid.org/0000-0002-9811-3585)
- Francielly Morena da Silva (ORCID: https://orcid.org/0000-0001-5019-2125)
- Ronald G. Jones
Institutions
- University of Arkansas at Fayetteville (US)
Publication Details
- Journal
- BMC Genomics
- Published
- 2025-10-09
- DOI
- https://doi.org/10.1186/s12864-025-12080-0
- Primary Topic
- Nutrition and Health in Aging
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Arkansas Biosciences Institute