SMAD4 mutation drives gut microbiome shifts toward tumor progression in colorectal cancer
These findings emphasize the significance of SMAD4 mutation and microbiome modulation, revealing the interaction between host genetics and gut microbiota in driving colorectal cancer aggressiveness and suggesting potential microbial targets.
Authors
- Subbaya Subramanian (ORCID: https://orcid.org/0000-0002-2544-480X)
- Travis J. Gates (ORCID: https://orcid.org/0000-0002-5276-6249)
- Dechen Wangmo (ORCID: https://orcid.org/0000-0001-6396-047X)
- Brittney N. Keel (ORCID: https://orcid.org/0000-0002-8099-0870)
- Kyra M. Boorsma Bergerud
- Christopher Staley (ORCID: https://orcid.org/0000-0001-7670-7545)
Institutions
- University of Minnesota Medical Center (US)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-10-09
- DOI
- https://doi.org/10.1007/s12672-025-02580-6
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00