Elucidating the role of IgA plasma cells and PECAM1-CD38 interaction in intestinal fibrosis: a single-cell RNA sequencing analysis in Crohn's disease
These findings may provide new insights into the mechanisms underlying early intestinal fibrosis in CD by identifying critical cell types and molecular players. Nonetheless, these observations are exploratory and will require validation in future experiments.
Authors
- Hua Jin (ORCID: https://orcid.org/0000-0002-1316-5512)
- Shuyang Sun (ORCID: https://orcid.org/0000-0001-6013-0614)
- S Y Du
- Yuqi He (ORCID: https://orcid.org/0000-0001-8930-2117)
- Jingyan Feng (ORCID: https://orcid.org/0000-0001-8626-3941)
- Limin Zhang (ORCID: https://orcid.org/0000-0001-5689-948X)
- Lei Li (ORCID: https://orcid.org/0000-0003-3661-4808)
- Kai Li
- Jiheng Wang (ORCID: https://orcid.org/0000-0002-5556-8731)
Institutions
- Peking University (CN)
- Chinese PLA General Hospital (CN)
- Beijing Jishuitan Hospital (CN)
- BeiGene (China) (CN)
- Beijing Chest Hospital (CN)
Publication Details
- Journal
- BMC Gastroenterology
- Published
- 2025-10-09
- DOI
- https://doi.org/10.1186/s12876-025-04312-0
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 0.00