Mineralocorticoid Receptor Antagonism Reduces Atrial Arrhythmias Post‐Cardiac Surgery and Attenuates Atrial Stress Responses to Cardioplegic Arrest
Preoperative MRAs were associated with reduced postoperative and long-term AF after cardiac surgery. Mechanistically, our ex-vivo human atrial model revealed that MRAs suppress mineralocorticoid receptor -driven atrial stress responses, particularly in conduction-relevant cardiomyocytes.
Authors
- Y. Eugene Chen (ORCID: https://orcid.org/0000-0003-2357-7825)
- Wenbin Gao (ORCID: https://orcid.org/0000-0001-9268-8823)
- Paul C. Tang (ORCID: https://orcid.org/0000-0003-4211-8587)
- Paul A. Friedman (ORCID: https://orcid.org/0000-0001-5052-2948)
- Aurora Lee (ORCID: https://orcid.org/0009-0000-4607-5188)
- Trevor C. Chopko (ORCID: https://orcid.org/0009-0005-1036-3635)
- Joseph J. Maleszewski (ORCID: https://orcid.org/0000-0003-3239-6460)
- Francis D. Pagani (ORCID: https://orcid.org/0000-0003-4430-9969)
- Marco Metra (ORCID: https://orcid.org/0000-0001-6691-8568)
- Ienglam Lei (ORCID: https://orcid.org/0000-0002-0248-6871)
- Vincent K.H Tam
- Fazal Khan (ORCID: https://orcid.org/0000-0001-6687-1528)
- Sina Danesh (ORCID: https://orcid.org/0000-0002-4042-417X)
- Ran Huo (ORCID: https://orcid.org/0000-0002-3513-1073)
- Hartzell Vernon Schaff (ORCID: https://orcid.org/0000-0003-0994-027X)
- Lu Shuyang
- Hakan Oral (ORCID: https://orcid.org/0000-0002-2237-0155)
- Austin L. Todd
- Bertram Pitt
Institutions
- Mayo Clinic (US)
- University of Michigan (US)
- WinnMed (US)
- Brescia University (US)
- Michigan Medicine (US)
- Mayo Clinic in Arizona (US)
- Mayo Clinic in Florida (US)
- University of Brescia (IT)
Publication Details
- Journal
- Journal of the American Heart Association
- Published
- 2025-10-09
- DOI
- https://doi.org/10.1161/jaha.125.043661
- Citations
- 1
- Primary Topic
- Hormonal Regulation and Hypertension
- Type
- article
- Field-Weighted Citation Impact
- 1.29