Germline and somatic mutational variants of Tunisian high grade serous ovarian cancer identified by next-generation sequencing
This study provides the first comprehensive genetic profiling of Tunisian HGSOC patients, highlighting the prevalence of pathogenic mutations in key cancer-related genes. These findings emphasize the importance of genetic screening in the management and treatment of OC particularly in populations with unique genetic backgrounds.
Authors
- Dorra BenAyed-Guerfali
- Hassen Kamoun (ORCID: https://orcid.org/0000-0002-1798-3862)
- Nihel Ammous-Boukhris (ORCID: https://orcid.org/0000-0002-5744-0328)
- Slim Charfi (ORCID: https://orcid.org/0000-0001-8497-9815)
- Wala Ben Kridis (ORCID: https://orcid.org/0000-0002-4956-9551)
- Rania Abdelmaksoud‐Dammak
- Jamel Daoud
- Ameni Feki
- Afef Khanfir
- Arwa Shtaiwi Abed
- Raja Mokdad‐Gargouri (ORCID: https://orcid.org/0000-0003-1319-0061)
- Souhir Guidara
- Tahia Sellami‐Boudawara
Institutions
- Hopital Universitaire Hedi Chaker (TN)
- Centre of Biotechnology of Sfax (TN)
- Hopital Universitaire Habib Bourguiba (TN)
Publication Details
- Journal
- BMC Cancer
- Published
- 2025-10-09
- DOI
- https://doi.org/10.1186/s12885-025-14989-x
- Primary Topic
- Ovarian cancer diagnosis and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00