Rectal metastasis as the initial presentation of primary lung adenocarcinoma with an EGFR L858R mutation: a case report
Although rectal metastasis harbouring EGFR L858R mutations from primary lung adenocarcinoma is extremely rare, clinicians should have a low threshold for pulmonary low-dose spiral CT. In addition, histopathologic analysis by immunohistochemistry combined with molecular diagnostics is critical for a timely and accurate diagnosis and to distinguish rectal metastases from primary rectal malignancies.
Authors
- Juanyi Wang
- Jianjun Li (ORCID: https://orcid.org/0000-0003-4402-5472)
- Rui Nian (ORCID: https://orcid.org/0000-0002-8316-5462)
- Xiang Li (ORCID: https://orcid.org/0000-0002-1098-7713)
- Wanjun Li (ORCID: https://orcid.org/0000-0002-7700-6203)
- Shushen Ji (ORCID: https://orcid.org/0009-0004-3052-3934)
- Huihui Jiang (ORCID: https://orcid.org/0000-0002-5046-305X)
- Ling Lin (ORCID: https://orcid.org/0000-0002-8573-1608)
- Mengzhu Wang
Institutions
- Shanghai Zhangjiang Laboratory (CN)
- First Affiliated Hospital of Xi'an Jiaotong University (CN)
- Xi'an Jiaotong University (CN)
Publication Details
- Journal
- World Journal of Surgical Oncology
- Published
- 2025-10-09
- DOI
- https://doi.org/10.1186/s12957-025-04016-5
- Primary Topic
- Metastasis and carcinoma case studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00