Elucidating multifaceted targets of Marein in cerebral ischemia-reperfusion injury
Marein exerts neuroprotective effects against CIRI by targeting PTGS2, SRC, and EGFR, modulating inflammatory and oxidative stress pathways. This study provides a mechanistic basis for Marein's potential in CIRI therapy.
Authors
- Jun Long (ORCID: https://orcid.org/0000-0002-4894-0953)
- Xinyao Huang
- Yang Su (ORCID: https://orcid.org/0000-0001-5390-8192)
- Xinwei Mao
- Ying Fan (ORCID: https://orcid.org/0000-0003-0044-6750)
- Jie Zhan (ORCID: https://orcid.org/0000-0001-6487-344X)
- Yi Zhong (ORCID: https://orcid.org/0000-0002-7927-5976)
- Xingxia Wang
- Tingting Tang (ORCID: https://orcid.org/0000-0002-1670-7452)
- Weidan Luo
- Xingchun Wang (ORCID: https://orcid.org/0000-0002-5601-3105)
- Jian Wang (ORCID: https://orcid.org/0000-0003-2291-640X)
- Yibo Zhang (ORCID: https://orcid.org/0000-0001-8673-5005)
- Wanying Xie (ORCID: https://orcid.org/0000-0002-3659-6841)
- Xinrui Wang (ORCID: https://orcid.org/0000-0001-7003-4917)
- Meng Yuan (ORCID: https://orcid.org/0009-0008-5869-147X)
Institutions
- Southwest Medical University (CN)
- Affiliated Hospital of Southwest Medical University (CN)
- First Affiliated Hospital of Sichuan Medical University (CN)
- Sichuan Cancer Hospital (CN)
Publication Details
- Journal
- Frontiers in Chemistry
- Published
- 2025-10-09
- DOI
- https://doi.org/10.3389/fchem.2025.1651873
- Primary Topic
- Neuroscience and Neuropharmacology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Southwest Medical University
- Affiliated Hospital of Southwest Medical University