Systemic T Cell Receptor Profiling Reveals Adaptive Immune Activation and Potential Immune Signatures of Diagnosis and Brain Atrophy in Epilepsy
Peripheral TCR repertoire profiling reveals that systemic immune dysregulation is present in epilepsy and is associated with neurodegeneration. Our findings highlight the peripheral TCR repertoire as a disease-relevant immune signature with the potential to non-invasively interrogate epilepsy status and guide therapeutic interventions.
Authors
- Sang Bin Hong (ORCID: https://orcid.org/0000-0001-8504-291X)
- Jangsup Moon (ORCID: https://orcid.org/0000-0003-1282-4528)
- Jaeseong Oh (ORCID: https://orcid.org/0000-0001-6275-8587)
- Yong Woo Shin (ORCID: https://orcid.org/0000-0002-9150-0355)
- Keun‐Hwa Jung (ORCID: https://orcid.org/0000-0003-1433-8005)
- Inpyeong Hwang (ORCID: https://orcid.org/0000-0002-1291-8973)
- Kyung‐Il Park (ORCID: https://orcid.org/0000-0001-8064-6749)
- Narae Kim (ORCID: https://orcid.org/0000-0002-9255-4144)
- Kon Chu (ORCID: https://orcid.org/0000-0001-5863-0302)
- Yong‐Won Shin (ORCID: https://orcid.org/0000-0002-6781-7782)
- Ji-Hyeon Choi
- Sang Kun Lee (ORCID: https://orcid.org/0000-0003-1908-0699)
Institutions
- Seoul National University Hospital (KR)
- Inha University Hospital (KR)
- Jeju National University Hospital (KR)
- Jeju National University (KR)
Publication Details
- Journal
- Annals of Clinical and Translational Neurology
- Published
- 2025-10-07
- DOI
- https://doi.org/10.1002/acn3.70203
- Primary Topic
- Autoimmune Neurological Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Research Foundation
- National Research Foundation of Korea