5,7-dimethoxyflavone inhibits hepatocellular carcinoma progression via increasing intestinal Akkermansia muciniphila and hepatic CD8+ T cell infiltration
DMF improves A. muciniphila-mediated intestinal barrier repair and inhibits the NF-κB/CCL2 pathway in HCC cells, enhancing the immunity of CD8<sup>+</sup> T cells in the liver. Hence, it may serve as a potential candidate for HCC treatment.
Authors
- Chang‐Shun Liu (ORCID: https://orcid.org/0000-0003-2841-1795)
- Yiqin Wang (ORCID: https://orcid.org/0000-0003-1575-1571)
- Wentao Jiang (ORCID: https://orcid.org/0000-0002-8274-389X)
- Xuemei Yang
- Weicong Chen (ORCID: https://orcid.org/0000-0003-0001-0906)
- G. Li
- Mengchen Qin
- Haitao Sun (ORCID: https://orcid.org/0000-0002-1939-8608)
- Yang Liu (ORCID: https://orcid.org/0000-0002-0959-3004)
- Xiao Li (ORCID: https://orcid.org/0000-0002-4233-3378)
- Bin Wen (ORCID: https://orcid.org/0000-0002-7870-1953)
- Songqi He
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Guangdong Provincial Hospital of Traditional Chinese Medicine (CN)
- Zhuhai Hospital of Integrated Traditional Chinese and Western Medicine (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Chinese Medicine
- Published
- 2025-10-08
- DOI
- https://doi.org/10.1186/s13020-025-01233-8
- Primary Topic
- MicroRNA in disease regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00