FRA1 (FOSL1) suppresses neoplastic transformation and modulates radiation responses via transcriptional control of mitogenic and stress-responsive networks
These findings establish FRA1 as a key modulator of neoplastic transformation and radiation response, acting primarily through transcriptional repression of pro-tumorigenic signaling pathways.
Authors
- Christopher Thome (ORCID: https://orcid.org/0000-0002-0160-9657)
- Wuroud Al-Khayyat
- Jessica Dougherty (ORCID: https://orcid.org/0000-0001-7065-0672)
- T.C. Tai (ORCID: https://orcid.org/0000-0001-7581-4234)
- Douglas R. Boreham (ORCID: https://orcid.org/0000-0001-7278-0171)
- Taylor Laframboise
- Marc S. Mendonca (ORCID: https://orcid.org/0000-0001-9139-1964)
- Sujeenthar Tharmalingam (ORCID: https://orcid.org/0009-0007-0415-4831)
Institutions
- Health Sciences North (CA)
- Laurentian University (CA)
- Indiana University – Purdue University Indianapolis (US)
- NOSM University (CA)
Publication Details
- Journal
- Frontiers in Cell and Developmental Biology
- Published
- 2025-09-22
- DOI
- https://doi.org/10.3389/fcell.2025.1659986
- Primary Topic
- Hippo pathway signaling and YAP/TAZ
- Type
- article
- Field-Weighted Citation Impact
- 0.00