HIV subtype-specific gp140-CD4 binding, Temsavir efficacy, and identification of novel adhesion inhibitors against Chinese HIV strains
This study elucidates the molecular mechanisms of HIV-1 adhesion variation and provides specific candidate HIV adhesion inhibitors for prevalent CRF subtypes in China. Subsequent efforts will focus on preclinical validation and structure-activity relationship optimization of these candidates, laying the groundwork for developing personalized therapeutic strategies against region-specific strains.
Authors
- Shengjie Zhang (ORCID: https://orcid.org/0000-0001-6988-2791)
- Lin Cheng (ORCID: https://orcid.org/0000-0001-8066-527X)
- Lanlan Wei (ORCID: https://orcid.org/0000-0002-6060-4303)
- Xiaolin Yang (ORCID: https://orcid.org/0000-0003-0992-8676)
- Yao Zhao (ORCID: https://orcid.org/0000-0002-2932-2164)
- Shanshan Tang (ORCID: https://orcid.org/0000-0001-7144-6788)
- Yao Wang (ORCID: https://orcid.org/0000-0002-9521-8680)
- Tianyang Liu (ORCID: https://orcid.org/0000-0003-2598-8572)
- Siwei Zhang (ORCID: https://orcid.org/0009-0005-0873-5217)
- Hongzhou Lu (ORCID: https://orcid.org/0000-0002-8308-5534)
- Xiaowen Li (ORCID: https://orcid.org/0000-0002-3058-0347)
- Fuxiang Wang
Institutions
- Jiamusi University (CN)
- Southern University of Science and Technology (CN)
- Affiliated Hospital of Southwest Medical University (CN)
- Third Affiliated Hospital of Southern Medical University (CN)
- Shenzhen Center for Disease Control and Prevention (CN)
- Shenzhen Second People's Hospital (CN)
- Shenzhen Third People’s Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-09-22
- DOI
- https://doi.org/10.3389/fimmu.2025.1648546
- Primary Topic
- HIV Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Fudan University
- School of Pharmacy, Fudan University
- Shenzhen Science and Technology Innovation Program