Retinal microvascular alterations in Alzheimer's disease: Linking blood plasma biomarkers and cerebral small vessel pathology
Retinal microvasculature assayed via color fundus photography (CFP) is sensitive to microvascular damage and can differentiate Alzheimer's disease (AD) from cognitively unimpaired controls. Retinal microvascular damage in AD is associated with phosphorylated tau [p-tau]181, p-tau217, p-tau217/amyloid beta (Aβ)42, and increased amyloid burden (lower Aβ42 and Aβ42/40). Retinal microvascular damage in AD is associated with increased cerebral small vessel burden.
Authors
- Caiyun Wen
- Huihua Qiu
- Carol Y. Cheung (ORCID: https://orcid.org/0000-0002-9672-1819)
- Vincent Mok (ORCID: https://orcid.org/0000-0002-8102-8835)
- William Robert Kwapong (ORCID: https://orcid.org/0000-0001-9633-4694)
- Chunwen Zheng (ORCID: https://orcid.org/0000-0003-2574-0446)
- Jingjing Qian (ORCID: https://orcid.org/0000-0003-4624-9963)
- Weihong Lin
- Xiaoqian Luan (ORCID: https://orcid.org/0000-0003-1395-4797)
- Youjie Wang (ORCID: https://orcid.org/0000-0001-7031-2972)
- Zhen Wang (ORCID: https://orcid.org/0000-0002-8581-4649)
- Yuntao Liu (ORCID: https://orcid.org/0000-0003-4033-2133)
- Jianing Shen (ORCID: https://orcid.org/0000-0003-4050-0299)
- Yinhe Liu (ORCID: https://orcid.org/0000-0002-2578-6308)
- Haoran Cheng
- Yunjun Yang
- Ning Wu (ORCID: https://orcid.org/0000-0002-4446-0338)
Institutions
- Chinese University of Hong Kong (HK)
- Capital Medical University (CN)
- Sichuan University (CN)
- Wenzhou Medical University (CN)
- First Affiliated Hospital of Wenzhou Medical University (CN)
- West China Hospital of Sichuan University (CN)
- Prince of Wales Hospital (CN)
- Zhejiang Mariculture Research Institute (CN)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1002/alz.70745
- Citations
- 4
- Primary Topic
- Retinal Imaging and Analysis
- Type
- article
- Field-Weighted Citation Impact
- 5.44
Funders
- Wenzhou Medical University