Intestinal inflammation induces glymphatic remodeling, priming early neurodegenerative signals in male mice
An acute peripheral inflammatory trigger affects the central level by remodeling central nervous system (CNS) fluid distribution and priming early signals of synaptopathy. A single dextran sulfate sodium (DSS) challenge disrupts the circadian clock machinery and alters CNS fluid distribution, a so far neglected system, thereby impairing glymphatic clearance of waste products and indirectly altering neurotransmitter release dynamics. These combined effects ultimately impact brain function, extending to the regulation of behavior. Understanding how an intestinal inflammatory insult may derange the daily rhythm of the mechanisms controlling brain waste disposal may help identify specific groups of subjects at high risk of developing neurological disorders.
Authors
- Cristina Lanni (ORCID: https://orcid.org/0000-0002-3061-4738)
- Giuseppina Mattace Raso (ORCID: https://orcid.org/0000-0002-5254-139X)
- Annapaola Andolfo (ORCID: https://orcid.org/0000-0002-0566-2391)
- Edoardo Pedrini (ORCID: https://orcid.org/0000-0002-2813-9261)
- Stefano Govoni (ORCID: https://orcid.org/0000-0002-7243-6837)
- Francesca Fagiani (ORCID: https://orcid.org/0000-0001-7722-0624)
- Rosaria Meli (ORCID: https://orcid.org/0000-0002-6246-6813)
- Clara Ciampi (ORCID: https://orcid.org/0000-0002-6455-2723)
- Luigia Trabace (ORCID: https://orcid.org/0000-0003-3073-8404)
- Valentina Murtaj (ORCID: https://orcid.org/0000-0003-0498-1478)
- Marta Filibian (ORCID: https://orcid.org/0000-0003-0939-7879)
- Clarissa Braccia (ORCID: https://orcid.org/0000-0002-6343-9614)
- Lorenzo Di Cesare Mannelli (ORCID: https://orcid.org/0000-0001-8374-4432)
- Federica Comella (ORCID: https://orcid.org/0000-0002-5192-3556)
- Vincent Torre (ORCID: https://orcid.org/0000-0001-8133-3584)
- Nicola Opallo
- Maria Grazia Bottone (ORCID: https://orcid.org/0000-0003-4570-8785)
- Anna Pittaluga (ORCID: https://orcid.org/0000-0002-4011-1165)
- María Bové (ORCID: https://orcid.org/0000-0001-8794-4247)
- Carla Ghelardini
- Elena Lucarini
Institutions
- University of Foggia (IT)
- University of Pisa (IT)
- Vita-Salute San Raffaele University (IT)
- University of Pavia (IT)
- Istituto Nazionale di Fisica Nucleare, Sezione di Pavia (IT)
- Federico II University Hospital (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele (IT)
- University of Florence (IT)
- University of Naples Federico II (IT)
- University of Genoa (IT)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1002/alz.70640
- Citations
- 1
- Primary Topic
- Cerebrospinal fluid and hydrocephalus
- Type
- article
- Field-Weighted Citation Impact
- 0.91