Gut microbiome and cognitive function in the Hispanic Community Health Study/Study of Latinos
BackgroundThere is limited work on the association between the gut microbiome and Alzheimer's disease and related dementia (AD/ADRD) in Latinos.ObjectiveWe examined, within the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) cohort, the association between gut microbiome and cognitive function.MethodsWe analyzed the fecal metagenomes of 2471 HCHS/SOL participants to identify microbial taxonomic and functional features associated with global cognitive function. Omnibus (PERMANOVA) and feature-wise analyses (MaAsLin2) were conducted to identify microbiome-cognition associations, and specific microbial species and pathways (Kyoto Encyclopedia of Genes and Genomes (KEGG modules) associated with cognition.Results<i>Eubacterium</i> species (<i>E. siraeum</i> and <i>E. eligens</i>), and <i>C phoceensis</i>, among other species were associated with better cognition. Several KEGG modules, most strongly Ornithine, Serine biosynthesis and Urea Cycle, were associated with worse cognition.ConclusionsIn a large Hispanic/Latino cohort, we identified several microbial taxa and KEGG pathways associated with cognition.
Authors
- Melissa Lamar (ORCID: https://orcid.org/0000-0001-6130-5543)
- Curtis Huttenhower (ORCID: https://orcid.org/0000-0002-1110-0096)
- Scott Paul Gordon (ORCID: https://orcid.org/0000-0002-3377-6548)
- Robert David Burk (ORCID: https://orcid.org/0000-0002-8376-8458)
- Rob Knight (ORCID: https://orcid.org/0000-0002-0975-9019)
- Robert C. Kaplan (ORCID: https://orcid.org/0000-0003-3271-801X)
- Qibin Qi (ORCID: https://orcid.org/0000-0002-2687-1758)
- Wassim Tarraf (ORCID: https://orcid.org/0000-0001-8888-7918)
- Héctor M. González (ORCID: https://orcid.org/0000-0001-8711-2627)
- Tomasz Kościółek (ORCID: https://orcid.org/0000-0002-9915-7387)
- Gregory Telavera
- Tao Wang (ORCID: https://orcid.org/0000-0003-0581-1251)
- Natalia Palacios
- Marta Daviglus
- Jianwen Cai (ORCID: https://orcid.org/0000-0002-4945-6733)
- Charles De Carli
Institutions
- Broad Institute (US)
- University of North Carolina at Chapel Hill (US)
- Albert Einstein College of Medicine (US)
- University of Massachusetts Lowell (US)
- Harvard University (US)
- University of San Diego (US)
- Illinois College (US)
- Wayne State University (US)
- San Diego State University (US)
- University of California System (US)
- University of California San Diego (US)
- University of Illinois Chicago (US)
- Fred Hutch Cancer Center (US)
- Office of Minority Health (US)
- VA New England Healthcare System (US)
- Precision for Medicine (United States) (US)
- Precision Research Institute (US)
- Institute for Minority Studies (HU)
- Rush University (US)
- University of California, Davis (US)
Publication Details
- Journal
- Journal of Alzheimer s Disease
- Published
- 2025-10-09
- DOI
- https://doi.org/10.1177/13872877251376911
- Citations
- 1
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.81