Estrogen Alleviates Myocardial Ischemia–Reperfusion Injury by Inhibiting NLRP3 Inflammasome‐Mediated Pyroptosis
Collectively, these results suggest that estrogen may alleviate myocardial I/R injury by inhibiting pyroptosis through the ER/TXNIP/NLRP3/Caspase-1 pathway, offering insights into potential therapeutic strategies for cardiac ischemic injury.
Authors
- Cheng Cheng (ORCID: https://orcid.org/0000-0001-9226-1547)
- Yutong Li (ORCID: https://orcid.org/0000-0003-1619-9803)
- Xiaochen Wang (ORCID: https://orcid.org/0000-0002-4344-0925)
- Banglong Xu
- Fei He (ORCID: https://orcid.org/0009-0000-5032-7333)
- Jianlong Sheng (ORCID: https://orcid.org/0000-0002-6080-5228)
- Jing Cheng (ORCID: https://orcid.org/0000-0003-1395-8026)
- Shichun Shen (ORCID: https://orcid.org/0000-0003-4925-4856)
Institutions
- University of Science and Technology of China (CN)
- Anhui Medical University (CN)
- Anhui University of Traditional Chinese Medicine (CN)
- First Affiliated Hospital of Anhui Medical University (CN)
- Second Affiliated Hospital of Anhui Medical University (CN)
Publication Details
- Journal
- Cardiology Research and Practice
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1155/crp/1850200
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China