Thermodynamic parameters of solubility of 1-cyclohexyl-2-methyl-5-phenyl-1h-pyrrole-3-carboxylic acid in organic solvents

The temperature dependence of the solubility of 1-cyclohexyl-2-methyl-5-phenyl-1 H -pyrrole-3-carboxylic acid in methyl acetate, ethyl acetate, acetonitrile, 1-butanol, 2-butanol, 1-propanol, 2-propanol was used to calculate the enthalpy and entropy of their dissolution. The nature of the interaction between solvents and the dissolved substance is determined. The temperature dependences of the solubility of 1-cyclohexyl-2-methyl-5-phenyl-1 H -pyrrole-3-carboxylic acid in various solvents are presented. Taking into account the enthalpy and entropy of melting recalculated to 298.15 K, the enthalpies and entropies of mixing were calculated. Keywords : solubility; enthalpy of dissolution, enthalpy of mixing, enthalpy of melting, pyrrole-3-carboxylic acid, polysubstituted pyrroles.