Protein Target Highlights in <scp>CASP16</scp> : Insights From the Structure Providers
This article presents an in-depth analysis of selected CASP16 targets, with a focus on their biological and functional significance. The authors highlight the most relevant features of the target proteins and discuss how well these were reproduced in the submitted predictions. While the overall performance of structure prediction methods remains impressive, challenges persist, particularly in modeling rare structural motifs, flexible regions, small molecule interactions, posttranslational modifications, and biologically important interfaces. Addressing these limitations can strengthen the role of structure prediction in complementing experimental efforts and advancing both basic research and biomedical applications.
Authors
- Daniel Fox (ORCID: https://orcid.org/0000-0003-0271-2776)
- Leila T. Alexander (ORCID: https://orcid.org/0000-0002-7594-2110)
- Sabrina Bibi‐Triki (ORCID: https://orcid.org/0000-0002-3169-6544)
- Shiheng Liu (ORCID: https://orcid.org/0000-0002-0561-1981)
- Alessio d’Acapito (ORCID: https://orcid.org/0000-0002-1534-4813)
- Morgan Jenkins
- John Moult (ORCID: https://orcid.org/0000-0002-3012-2282)
- Tomas Malinauskas (ORCID: https://orcid.org/0000-0002-4847-5529)
- Rebecca M. DuBois (ORCID: https://orcid.org/0000-0003-4185-5673)
- Loïc Carrique (ORCID: https://orcid.org/0000-0001-5332-8593)
- Cécile Breyton (ORCID: https://orcid.org/0000-0002-4382-0434)
- Kim Ivan A. Abesamis
- Gerald Lackner (ORCID: https://orcid.org/0000-0002-0307-8319)
- Deborah Fass (ORCID: https://orcid.org/0000-0001-9418-6069)
- Michael Lammers (ORCID: https://orcid.org/0000-0003-4168-4640)
- Juliana A. Martinez Fiesco (ORCID: https://orcid.org/0000-0002-2396-0974)
- Christian Siebold (ORCID: https://orcid.org/0000-0002-6635-3621)
- Gang Dong (ORCID: https://orcid.org/0000-0001-9745-8103)
- Françoise Bringel (ORCID: https://orcid.org/0000-0002-4529-5143)
- Z. Hong Zhou (ORCID: https://orcid.org/0000-0002-8373-4717)
- J.R. Keown (ORCID: https://orcid.org/0000-0003-0159-9257)
- Torsten Schwede (ORCID: https://orcid.org/0000-0003-2715-335X)
- Jonathan M. Grimes (ORCID: https://orcid.org/0000-0001-9698-0389)
- Gottfried J. Palm (ORCID: https://orcid.org/0000-0003-0329-0413)
- Maya Topf (ORCID: https://orcid.org/0000-0002-8185-1215)
- Rhys W. Grinter (ORCID: https://orcid.org/0000-0002-8195-5348)
- Roman Kamyshinsky (ORCID: https://orcid.org/0000-0002-8546-7763)
- Krzysztof Fidelis (ORCID: https://orcid.org/0000-0002-8061-412X)
- Ping Zhang (ORCID: https://orcid.org/0000-0002-0340-281X)
- Benoı̂t Masquida (ORCID: https://orcid.org/0000-0002-6565-2099)
- Andrew L. Lovering (ORCID: https://orcid.org/0000-0002-1856-7975)
- Océane M. Follonier (ORCID: https://orcid.org/0009-0002-2577-1808)
- H. E. Box
- Tiantian Su (ORCID: https://orcid.org/0000-0002-9412-5503)
- Andriy Kryshtafovych (ORCID: https://orcid.org/0000-0001-5066-7178)
Institutions
- SIB Swiss Institute of Bioinformatics (CH)
- Centre National de la Recherche Scientifique (FR)
- Centre for Human Genetics (GB)
- California NanoSystems Institute (US)
- Universität Hamburg (DE)
- University of California, Los Angeles (US)
- The University of Melbourne (AU)
- University of Basel (CH)
- University of California, Santa Cruz (US)
- Commissariat à l'Énergie Atomique et aux Énergies Alternatives (FR)
- Universitätsmedizin Greifswald (DE)
- Discovery Institute (US)
- Australian Regenerative Medicine Institute (AU)
- Deutsches Elektronen-Synchrotron DESY (DE)
- Max Perutz Labs (AT)
- CEA Grenoble (FR)
- Universität Greifswald (DE)
- University of Warwick (GB)
- University of Oxford (GB)
- University Medical Center Hamburg-Eppendorf (DE)
- Department of Biomedicine Basel (CH)
- Frederick National Laboratory for Cancer Research (US)
- Research Institute for Bioscience and Biotechnology (NP)
- Vienna Biocenter (AT)
- Institut de Biologie Structurale (FR)
- Advanced Bioscience Laboratories (United States) (US)
- Centre for Structural Systems Biology (DE)
- Institute for Bioscience and Biotechnology Research
- Weizmann Institute of Science (IL)
- University of Bayreuth (DE)
- Monash University (AU)
- Monash Institute of Medical Research (AU)
- Université de Strasbourg (FR)
- Medical University of Vienna (AT)
- University of Birmingham (GB)
- University of California, Davis (US)
- Université Grenoble Alpes (FR)
Publication Details
- Journal
- Proteins Structure Function and Bioinformatics
- Published
- 2025-10-09
- DOI
- https://doi.org/10.1002/prot.70025
- Citations
- 1
- Primary Topic
- Protein Structure and Dynamics
- Type
- article
- Field-Weighted Citation Impact
- 0.81