Dual Role of Factor H–Related Protein 1 in IgA Nephropathy Kidney Injury
FHR-1 exacerbates kidney injury in IgAN by accelerating complement activation and inflammation. FHR-1<sub>SCR1-2</sub> effectively attenuated FHR-1-induced inflammation, demonstrating promising therapeutic potential for IgAN.
Authors
- Sufang Shi (ORCID: https://orcid.org/0000-0002-8949-7054)
- Xianzhi Li (ORCID: https://orcid.org/0000-0002-3653-4448)
- Jicheng Lv (ORCID: https://orcid.org/0000-0001-9238-9508)
- Yuqi Kang (ORCID: https://orcid.org/0000-0003-0246-248X)
- Hong Zhang (ORCID: https://orcid.org/0000-0002-1770-6582)
- Li Zhu (ORCID: https://orcid.org/0000-0002-9051-6603)
- Xiaohan Yuan
Institutions
- Peking University (CN)
- Peking University First Hospital (CN)
- Peking University Third Hospital (CN)
Publication Details
- Journal
- Kidney International Reports
- Published
- 2025-10-09
- DOI
- https://doi.org/10.1016/j.ekir.2025.09.047
- Primary Topic
- Renal Diseases and Glomerulopathies
- Type
- article
- Field-Weighted Citation Impact
- 0.00