HBV X protein regulates cancer stemness and tumor invasiveness through SENP1 in hepatocellular carcinoma
Early recurrence, tumor metastasis, and drug resistance are significant therapeutic challenges in hepatocellular carcinoma (HCC), which are closely associated with cancer stem cell (CSC)-related properties. In this study, we demonstrated that HBx-induced SENP1 expression regulates CSC-related properties and tumor metastasis, particularly in HBV-related HCC, in clinical, <i>in vitro</i>, and <i>in vivo</i> settings. Findings from this research highlight that HBx-induced SENP1 is crucial for promoting CSC-associated properties in HCC. SENP1 could serve as a novel biomarker of early tumor recurrence and metastasis, especially for HBV-related HCC.
Authors
- Kam-Fai Lee (ORCID: https://orcid.org/0000-0002-6357-5341)
- Yu-Chih Wu (ORCID: https://orcid.org/0000-0001-5781-2665)
- Hsiao-Feng Wang
- Te‐Sheng Chang (ORCID: https://orcid.org/0000-0002-1581-6948)
- Yen‐Hua Huang (ORCID: https://orcid.org/0000-0001-6937-2660)
- Mai-Huong Thi Ngo (ORCID: https://orcid.org/0009-0009-4026-8099)
- Shin-Lian Doong (ORCID: https://orcid.org/0000-0002-0936-3858)
- Yung‐Che Kuo (ORCID: https://orcid.org/0000-0002-9425-7389)
- Yu-Jie Huang (ORCID: https://orcid.org/0000-0002-5729-3305)
- Liang-Mou Kuo
- Y C Sung
Institutions
- National Sun Yat-sen University (TW)
- National Taiwan University (TW)
- Chang Gung University (TW)
- Taipei Medical University Hospital (TW)
- Chiayi Chang Gung Memorial Hospital (TW)
- Taipei Medical University (TW)
Publication Details
- Journal
- JHEP Reports
- Published
- 2025-10-09
- DOI
- https://doi.org/10.1016/j.jhepr.2025.101620
- Primary Topic
- Hepatitis B Virus Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Science Council
- Shanghai Educational Development Foundation
- Taipei Medical University
- National Taiwan University
- National Science and Technology Council