MBNL1 Modulates Nek7 to Facilitate Pathological Cardiac Hypertrophy via NLRP3
Nek7 drives pathological cardiac hypertrophy by activating the NLRP3 inflammasome and promoting cardiomyocyte pyroptosis, with MBNL1 acting as an upstream regulator. Targeting the MBNL1-Nek7-NLRP3 axis may offer a novel therapeutic strategy for preventing cardiac hypertrophy and heart failure.
Authors
- Mingxiu Zhang (ORCID: https://orcid.org/0000-0001-7628-4060)
- Haihai Liang (ORCID: https://orcid.org/0000-0003-4446-7035)
- Linzhu Wang
- Tong Yu
- Lifang Lv (ORCID: https://orcid.org/0000-0002-8538-8440)
- Xiaona Wang (ORCID: https://orcid.org/0000-0001-8710-1688)
- Ruonan Yang (ORCID: https://orcid.org/0009-0008-7701-8790)
- Xuelian Li (ORCID: https://orcid.org/0000-0001-9043-8580)
- Chao Li (ORCID: https://orcid.org/0000-0003-1568-9704)
- Tianyu Li (ORCID: https://orcid.org/0000-0003-3719-4892)
- Ying Zhang (ORCID: https://orcid.org/0000-0002-9556-361X)
- Juan Dong
- Yao Liu (ORCID: https://orcid.org/0000-0002-6393-4295)
- Bai‐Yan Li (ORCID: https://orcid.org/0000-0002-1853-0216)
- Hongli Shan (ORCID: https://orcid.org/0000-0001-9781-4411)
- Liangliang Li (ORCID: https://orcid.org/0009-0008-5493-4809)
Institutions
- Ministry of Education of the People's Republic of China (CN)
- Harbin Medical University (CN)
- Frontier Science Foundation (CH)
- Ningbo University Affiliated Hospital (CN)
- Ningbo First Hospital (CN)
Publication Details
- Journal
- Hypertension
- Published
- 2025-10-09
- DOI
- https://doi.org/10.1161/hypertensionaha.125.24641
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00