Atf3 Deficiency Promotes Mesodermal Commitment and Enhances Endothelial Differentiation in Embryonic Stem Cells
Atf3KO directs embryonic stem cells toward the mesodermal lineage and activates the Rap1 signaling pathway, thereby promoting ECs development. These findings highlight a key role of Atf3 in regulating early stage of vascular endothelial development.
Authors
- Cuiting Chen
- Zide Jiang (ORCID: https://orcid.org/0000-0002-1274-4627)
- Dandan Dai
- Man Wu (ORCID: https://orcid.org/0000-0001-6450-007X)
- Lide Su (ORCID: https://orcid.org/0000-0003-3701-8477)
- Y. Shu
- A. Guo (ORCID: https://orcid.org/0000-0001-8735-604X)
- Zonghong Liu
- Ronghai He (ORCID: https://orcid.org/0000-0002-0904-0522)
- Lili Jiang (ORCID: https://orcid.org/0000-0002-8972-4253)
- Suhuan Liu (ORCID: https://orcid.org/0000-0002-9192-2646)
- Jianlei Liu
Institutions
- Xiamen University (CN)
- First Affiliated Hospital of Xiamen University (CN)
Publication Details
- Journal
- Arteriosclerosis Thrombosis and Vascular Biology
- Published
- 2025-10-09
- DOI
- https://doi.org/10.1161/atvbaha.125.323063
- Primary Topic
- Pluripotent Stem Cells Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00