Zbp1 promotes atherosclerosis and lesion necrosis in mice
Zbp1 is an atherosclerosis modifier gene, similar to the canonical necroptosis genes Ripk1 and Mlkl. Higher expression of Zbp1 in DBA/2 mice may play a role in this strain having the largest lesions of all strains tested in the Apoe-deficient background.
Authors
- Jonathan D. Smith (ORCID: https://orcid.org/0000-0002-0415-386X)
- Juying Han (ORCID: https://orcid.org/0000-0002-3416-2433)
- Gregory Brubaker (ORCID: https://orcid.org/0000-0002-3882-8415)
- Emmanuel Opoku (ORCID: https://orcid.org/0000-0003-2816-7761)
Institutions
- Cleveland Clinic Lerner College of Medicine (US)
Publication Details
- Journal
- Atherosclerosis
- Published
- 2025-10-09
- DOI
- https://doi.org/10.1016/j.atherosclerosis.2025.120542
- Primary Topic
- RNA regulation and disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00