Exploring the Population Pharmacokinetic and Pharmacogenetics Characteristics of Flurbiprofen Isomers in Selective Joint Replacement Patients with Postoperative Pain
Key covariates of S (+)-flurbiprofen was ABCB1 gene polymorphisms and R-flurbiprofen was POR gene polymorphisms and BSA. The findings may provide support for future dose optimization and the development of novel therapeutic approaches.
Authors
- Xingxian Luo
- Yi Feng (ORCID: https://orcid.org/0000-0002-3952-1351)
- Hong Zhang (ORCID: https://orcid.org/0000-0002-4392-7370)
- Jinjie Yuan
- Han Yao (ORCID: https://orcid.org/0000-0002-6175-8072)
- Haiyan An (ORCID: https://orcid.org/0000-0002-3851-9663)
Institutions
- Peking University (CN)
- Soochow University (CN)
- Peking University People's Hospital (CN)
- First Affiliated Hospital of Soochow University (CN)
Publication Details
- Journal
- Drug Design Development and Therapy
- Published
- 2025-10-01
- DOI
- https://doi.org/10.2147/dddt.s542722
- Primary Topic
- Inflammatory mediators and NSAID effects
- Type
- article
- Field-Weighted Citation Impact
- 0.00