Esaxerenone inhibits renal macrophage proliferation through MR/TGF-β1 pathway in db/db mice
Esaxerenone inhibits renal macrophage proliferation mediated by high glucose-induced activation of MR and downstream TGF-β1 signaling pathways, thereby mitigating inflammatory and fibrotic damage. These findings suggest that MR blockade may directly target macrophage proliferation and inflammation in DKD.
Authors
- Jinchuan Tan (ORCID: https://orcid.org/0000-0002-7406-5400)
- FanYang
- Ziqian Liu (ORCID: https://orcid.org/0000-0003-4289-5802)
- Tatsuo Shimosawa (ORCID: https://orcid.org/0000-0002-8742-5129)
- Panpan Qiang (ORCID: https://orcid.org/0000-0002-3622-8803)
- Yuan Li (ORCID: https://orcid.org/0009-0000-0126-1331)
- Fengwen Yang
- Ruyan Lv
- Qingyou Xu
- Yicong Zhao (ORCID: https://orcid.org/0009-0008-1738-8335)
Institutions
- Hebei University of Chinese Medicine (CN)
- International University of Health and Welfare (JP)
Publication Details
- Journal
- Life Sciences
- Published
- 2025-10-09
- DOI
- https://doi.org/10.1016/j.lfs.2025.124008
- Citations
- 1
- Primary Topic
- Electrolyte and hormonal disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.52