Development of 3D Bioprinted Vascularized Cardiac Tissues Using Patient-Derived Stem Cells: A Preclinical Study

Regenerative therapies for myocardial infarction require viable vascularized cardiac tissues. We report the development of 3D bioprinted cardiac patches using patient-derived induced pluripotent stem cells (iPSCs) and endothelial progenitor cells. Bioprinted tissues exhibited spontaneous contraction, vascular network formation, and appropriate electromechanical coupling. In a rat myocardial infarction model, transplanted patches improved cardiac function and reduced scar size significantly. This work paves the way for personalized cardiac regenerative therapies.