Harnessing the potential of medicinal plants in the malaria fighting: In vitro and in vivo antiplasmodial activities of Feretia apodanthera Delille (Rubiaceae)
Overall, all three organs of F. apodanthera exhibited antiplasmodial activity both in vitro and in vivo while remaining non-toxic. The leaf demonstrated superior chemosuppressive and schizonticidal activity, along with strong trophozoitocidal effects, whereas the root and stem bark excelled in trophozoitocidal activity. These findings support the traditional use of F. apodanthera in malaria treatment and highlight its potential for developing antimalarial phytomedicines.
Authors
- Virginie Vaissayre
- Nâg-Tiero Roland Meda
- Mohamed Haddad (ORCID: https://orcid.org/0000-0001-5599-9980)
- Rakiswendé Serge Yerbanga (ORCID: https://orcid.org/0000-0001-8345-0880)
- Thierry Léfèvre (ORCID: https://orcid.org/0000-0002-9736-6142)
- Zachari Kabré
- Stéphane Dussert (ORCID: https://orcid.org/0000-0001-5222-4282)
- Domonbabélé François de Sales Hien (ORCID: https://orcid.org/0000-0002-8136-2702)
- Abdoulaye DIABATÉ
- Mariam Youba
- Saamou Isaac Boni (ORCID: https://orcid.org/0009-0004-4107-1814)
- Kouliga Benjamin Koama
Institutions
- Centre National de la Recherche Scientifique (FR)
- Université Toulouse III - Paul Sabatier (FR)
- Université Fédérale de Toulouse Midi-Pyrénées (FR)
- Université de Montpellier (FR)
- Agropolis International (FR)
- Nazi Boni University (BF)
- Maladies Infectieuses et Vecteurs: Écologie, Génétique, Évolution et Contrôle (FR)
- Diversité, adaptation et développement des plantes (FR)
- Pharmacochimie et Biologie pour le Développement (FR)
- Institut de Recherche en Sciences de la Santé (BF)
- Institut de Recherche pour le Développement (FR)
Publication Details
- Journal
- Journal of Ethnopharmacology
- Published
- 2025-10-09
- DOI
- https://doi.org/10.1016/j.jep.2025.120729
- Primary Topic
- Ethnobotanical and Medicinal Plants Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00