Influence of Obesity and IL-6 on Human Postprandial Amino Acid and Protein Metabolism at Whole-body and Tissue Level
Obesity impairs meal-induced muscle-protein gain, through insufficient suppression of protein degradation. Basal IL-6 activity does not regulate muscle protein turnover but influences amino acid metabolism and protein synthesis in extramuscular tissues.
Authors
- Ulrik Winning Iepsen (ORCID: https://orcid.org/0000-0002-8140-2583)
- Anton Lund (ORCID: https://orcid.org/0000-0002-0464-8328)
- Gerrit van Hall (ORCID: https://orcid.org/0000-0002-2519-8127)
- Alexandra Vassilieva (ORCID: https://orcid.org/0000-0002-9476-5850)
- Beckey Trinh (ORCID: https://orcid.org/0000-0003-2784-7079)
- Kirsten Møller (ORCID: https://orcid.org/0000-0003-3058-1072)
- Bente Klarlund Pedersen (ORCID: https://orcid.org/0000-0001-6508-6288)
- Helga Ellingsgaard (ORCID: https://orcid.org/0000-0002-9105-5247)
- Sten Rasmussen (ORCID: https://orcid.org/0000-0002-8664-352X)
- Susanne Janum
- Ana Rita Tavanez
- Mathilde Ehnhuus Brøgger-Jensen
Institutions
- University of Copenhagen (DK)
- Bispebjerg Hospital (DK)
- Hvidovre Hospital (DK)
- Copenhagen University Hospital (DK)
- Rigshospitalet (DK)
Publication Details
- Journal
- The Journal of Clinical Endocrinology & Metabolism
- Published
- 2025-10-08
- DOI
- https://doi.org/10.1210/clinem/dgaf547
- Primary Topic
- Muscle metabolism and nutrition
- Type
- article
- Field-Weighted Citation Impact
- 0.00