P4HB regulates tumor-associated macrophage polarization and chemotaxis by enhancing IL-6 cytokine secretion in glioblastoma
These findings establish P4HB as a regulator of glioma progression via IL-6/STAT3-mediated microglial polarization, highlighting its potential as a therapeutic target for GBM.
Authors
- Minkai Wang
- Dongling Pei
- Wenqing Wang (ORCID: https://orcid.org/0000-0002-4065-2316)
- Zilong Wang (ORCID: https://orcid.org/0009-0009-8981-9541)
- Ran Li (ORCID: https://orcid.org/0000-0003-3899-0612)
- Zeyu Ma (ORCID: https://orcid.org/0000-0002-3823-502X)
- Xiaotao Wang (ORCID: https://orcid.org/0000-0002-4131-7763)
- Xianzhi Liu (ORCID: https://orcid.org/0000-0002-6646-273X)
- Zhenyu Zhang (ORCID: https://orcid.org/0000-0002-4686-9241)
Institutions
- Henan Academy of Sciences (CN)
- First Affiliated Hospital of Zhengzhou University (CN)
- Hangzhou City University
Publication Details
- Journal
- Annals of Medicine and Surgery
- Published
- 2025-10-09
- DOI
- https://doi.org/10.1097/ms9.0000000000004049
- Primary Topic
- Nuclear Receptors and Signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.00