A multifunctional theranostic ultrasound platform for remote magnetogenetics and expanded blood-brain barrier opening
The results presented herein not only demonstrate the feasibility for ThUS to facilitate a non-invasive brain stimulation approach, but also showcase a method for eliciting larger volumes of BBB opening within a single sonication which could dramatically improve gene delivery procedures for both preclinical research and therapeutic purposes in the future.
Authors
- Elisa E. Konofagou (ORCID: https://orcid.org/0000-0002-9636-7936)
- Quoc-Khanh Pham (ORCID: https://orcid.org/0000-0001-9283-4835)
- Alec J. Batts (ORCID: https://orcid.org/0000-0002-6979-9389)
- Guillaume Duret (ORCID: https://orcid.org/0000-0003-1910-9025)
- Nancy Kwon (ORCID: https://orcid.org/0000-0002-7453-4609)
- Gang Bao (ORCID: https://orcid.org/0000-0001-5501-554X)
- Robin Ji (ORCID: https://orcid.org/0000-0003-1361-141X)
- Samantha Gorman (ORCID: https://orcid.org/0009-0006-4923-7940)
- Jeannette Ingabire (ORCID: https://orcid.org/0000-0002-7308-3068)
- Rebecca L. Noel (ORCID: https://orcid.org/0000-0003-3478-7254)
- Jacob T. Robinson (ORCID: https://orcid.org/0000-0002-3509-3054)
- Fotios N. Tsitsos (ORCID: https://orcid.org/0009-0000-1273-2311)
- Linlin Zhang (ORCID: https://orcid.org/0000-0003-3240-1215)
- Deny Tsakri
Institutions
- Rice University (US)
- Columbia University (US)
Publication Details
- Journal
- Brain stimulation
- Published
- 2025-10-09
- DOI
- https://doi.org/10.1016/j.brs.2025.10.006
- Primary Topic
- Ultrasound and Hyperthermia Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health
- Defense Advanced Research Projects Agency
- University of North Carolina at Chapel Hill
- Advanced Research Projects Agency
- Naval Information Warfare Center Pacific