Plasmablastic lymphoma in Crohn’s disease complicated by enterocutaneous fistula: Radiologic clues and interventional strategy

Plasmablastic lymphoma (PBL) is a rare and aggressive subtype of diffuse large B-cell lymphoma. The potential association between Crohn's disease and lymphoproliferative disorders remains controversial. We present an unusual case of plasmablastic lymphoma arising in a patient with long-standing rectocolonic Crohn's disease, complicated by an enterocutaneous fistula. The patient underwent surgery including sigmoidectomy, fistula disconnection, colostomy, and wide skin excision. Histopathology confirmed plasmablastic lymphoma involving the colon, rectum, and skin. Our case is notable for the challenging Diagnosis due to overlapping clinical features with Crohn's disease and often requires histological and immunophenotypic confirmation. This case underscores the importance of maintaining a high index of suspicion for malignancy in chronic inflammatory lesions. Further research is warranted to clarify the pathophysiological link between Crohn's disease and PBL, as well as the potential role of immunosuppression.