Haplo‐Identical Stem Cell Transplant Resolves Ventricular Arrhythmias and Dysfunction in a Sickle Cell Anemia Patient: Case Report and Discussion
A Sickle Cell Anemia patient with severe ventricular arrhythmia and left ventricular dysfunction achieved rapid, complete cardiac recovery after haplo-identical stem cell transplantation, raising questions about SCA cardiac pathophysiology and highlighting the potential for reversible cardiac complications following curative treatment. <b>Trial Registration</b>: The authors have confirmed clinical trial registration is not needed for this submission.
Authors
- Nicolas Lellouche (ORCID: https://orcid.org/0000-0001-8462-2218)
- Gonzalo De Luna (ORCID: https://orcid.org/0000-0003-4138-4218)
- I. Genty
- Sébastien Maury (ORCID: https://orcid.org/0000-0002-1170-8683)
- Vincent Parinet
- Pablo Bartolucci
- Rabah Redjoul
- Laurent Boyer (ORCID: https://orcid.org/0000-0002-2608-6696)
- Florence Beckerich
- Thomas d’Humières (ORCID: https://orcid.org/0000-0002-0414-0962)
- Geneviève Dérumeaux (ORCID: https://orcid.org/0000-0003-1471-1631)
- Sihem Iles
- Anoosha Habibi
- Thibaut Moulin (ORCID: https://orcid.org/0000-0002-6025-6644)
Institutions
- Inserm (FR)
- Université Paris-Est Créteil (FR)
- Université Paris Cité (FR)
- Centre Hospitalier Universitaire Henri-Mondor (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Hôpitaux Universitaires Henri-Mondor (FR)
- Paris Cardiovascular Research Center (FR)
- Hôpital Intercommunal de Créteil (FR)
- Institut Mondor de Recherche Biomédicale (FR)
Publication Details
- Journal
- eJHaem
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1002/jha2.70161
- Primary Topic
- Hemoglobinopathies and Related Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fédération Française de Cardiologie