Neuronal activity-dependent gene expression is stimulus-specific and changes with neuronal maturation
These findings hold both technical and conceptual significance. Technically, they underscore the importance of accounting for neuronal maturation and activation protocols when studying gene expression. Conceptually, they demonstrate that neuronal development and drug-induced firing patterns generate distinct expression profiles, which could be crucial for a deeper understanding of transcription-dependent plasticity mechanisms.
Authors
- Ariel Chernomoretz (ORCID: https://orcid.org/0000-0003-2675-353X)
- Antonia Marín‐Burgin (ORCID: https://orcid.org/0000-0003-0684-9796)
- Sebastián Kadener (ORCID: https://orcid.org/0000-0003-0080-5987)
- Jerónimo Lukin (ORCID: https://orcid.org/0000-0002-2284-7152)
- Olivia Pedroncini (ORCID: https://orcid.org/0009-0009-0613-4126)
- Maximiliano S. Beckel (ORCID: https://orcid.org/0000-0002-2284-9529)
- G Mauro (ORCID: https://orcid.org/0000-0001-5685-090X)
- Damián Refojo (ORCID: https://orcid.org/0000-0002-9798-6413)
- Sebastián A. Giusti (ORCID: https://orcid.org/0000-0002-0257-3027)
- Inés Lucía Patop (ORCID: https://orcid.org/0000-0002-2929-0860)
- Ivana Linenberg (ORCID: https://orcid.org/0000-0003-0436-2079)
Institutions
- Consejo Nacional de Investigaciones Científicas y Técnicas (AR)
- Universidad de Buenos Aires (AR)
- Fundación Instituto Leloir (AR)
- Max Planck Institute of Psychiatry (DE)
- Biomedicine Research Institute of Buenos Aires - CONICET - Partner Institute of the Max Planck Society (AR)
- Brandeis University (US)
Publication Details
- Journal
- Frontiers in Molecular Neuroscience
- Published
- 2025-10-09
- DOI
- https://doi.org/10.3389/fnmol.2025.1609772
- Citations
- 1
- Primary Topic
- RNA Research and Splicing
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- National Science Foundation
- Volkswagen Foundation
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Consejo Nacional de Investigaciones Científicas y Técnicas
- Max-Planck-Gesellschaft
- Agencia Nacional de Promoción Científica y Tecnológica