Sex differences in outcomes of vitamin K antagonist treatment in patients with a mechanical heart valve: a Dutch population-based cohort study
Women with MHVs aged <55 years exhibited poorer quality of VKA treatment and higher rates of complications than similarly aged men. These findings highlight the need for tailored anticoagulation strategies in younger female MHV patients.
Authors
- C.E.A. Dronkers
- Frank W.G. Leebeek (ORCID: https://orcid.org/0000-0001-5677-1371)
- Roger K. Schindhelm (ORCID: https://orcid.org/0000-0003-2151-6287)
- Martin E W Hemels (ORCID: https://orcid.org/0000-0002-2373-9858)
- Jaap Seelig (ORCID: https://orcid.org/0000-0003-0191-0244)
- Henk J Adriaansen (ORCID: https://orcid.org/0000-0003-0444-0436)
- Suzanne C. Cannegieter (ORCID: https://orcid.org/0000-0003-4707-2303)
- Chantal Visser (ORCID: https://orcid.org/0000-0002-2025-1734)
- Marieke J. H. A. Kruip (ORCID: https://orcid.org/0000-0002-0265-4871)
- Qingui Chen (ORCID: https://orcid.org/0000-0001-9669-0007)
- Hugo Ten Cate (ORCID: https://orcid.org/0000-0001-7796-4463)
- Melchior C. Nierman (ORCID: https://orcid.org/0000-0002-8647-7509)
- Arina J. ten Cate‐Hoek (ORCID: https://orcid.org/0000-0002-9900-6212)
- Nynke M. Wiersma
- Eva K Kempers (ORCID: https://orcid.org/0000-0001-9458-8674)
- Frederikus Albertus Klok (ORCID: https://orcid.org/0000-0001-9961-0754)
- Ron Pisters (ORCID: https://orcid.org/0000-0001-8965-0664)
- Maryam Kavousi (ORCID: https://orcid.org/0000-0001-5976-6519)
- Raffaele De Caterina (ORCID: https://orcid.org/0000-0003-1637-574X)
- Maarten Beinema (ORCID: https://orcid.org/0000-0001-6533-5416)
- Alexander Stork
- Laura M. Faber
Institutions
- University of Pisa (IT)
- Radboud University Nijmegen (NL)
- Leiden University Medical Center (NL)
- Maastricht University Medical Centre (NL)
- Erasmus MC (NL)
- Radboud University Medical Center (NL)
- Maastricht University (NL)
- Thrombosis Research Institute (IN)
- Thrombosis Research Institute (GB)
- Isala (NL)
- Medicines Evaluation Board (NL)
- Amsterdam University Medical Centers (NL)
- Rijnstate Hospital (NL)
- Deventer Ziekenhuis (NL)
- St. Anna Ziekenhuis (NL)
- Medisch Centrum Alkmaar (NL)
- Erasmus University Rotterdam (NL)
Publication Details
- Journal
- Journal of Thrombosis and Haemostasis
- Published
- 2025-10-09
- DOI
- https://doi.org/10.1016/j.jtha.2025.09.010
- Citations
- 1
- Primary Topic
- Atrial Fibrillation Management and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 1.39