Review on Simple Spectrofluorimetric Method for Neurotransmitters Estimation in Brain Tissues of Laboratory Animals

Neurotransmitters are low-molecular weight compounds that chemically transfer the electrical impulse from one neuron to another. Neurotransmitters are responsible for the functioning of the central nervous system. Neurotransmitters estimation is one of the major parameters for neuroendocrinology research scientists. The neurotransmitters are good indicators of proper functioning and better assessment of the physiochemical functioning of brain towards acute or chronic intake of extraneous chemical or drug. If adverse effects caused by any exogenous factor on brain can be proven by the helping selection of specific neurotransmitters markers into the brain tissue homogenate. Therefore, this review article highlights firstly the impact of neurotransmitters and associated functions. Secondly, describe the different relevant methods related to neurotransmitters (γ-aminobutyric acid-GABA, dopamine-DA, noradrenaline-NA, adrenaline-A and serotonin-5HT) estimation in wet tissue of brain of laboratory animals. Keywords: γ-aminobutyric acid, Dopamine, Noradrenaline, Adrenaline, Serotonin