Risk of stroke associated with risperidone in dementia with and without comorbid cardiovascular disease: population-based matched cohort study
People with dementia with a prior history of CVD are at a significant increased risk of stroke, and risperidone further exacerbates this risk. Moreover, risperidone increases risk of stroke in patients without a prior history of CVD. This quantification of stroke risk across subgroups with and without history of CVD may help with communication of risk and aid more judicious prescribing.
Authors
- Katherine Young (ORCID: https://orcid.org/0000-0003-2570-3864)
- John Dennis (ORCID: https://orcid.org/0000-0002-7171-732X)
- Clive Ballard (ORCID: https://orcid.org/0000-0003-0022-5632)
- William Henley (ORCID: https://orcid.org/0000-0001-6273-2619)
- Christoph Mueller (ORCID: https://orcid.org/0000-0001-9816-1686)
- Alys Wyn Griffiths (ORCID: https://orcid.org/0000-0001-9388-9168)
- Nefyn Williams (ORCID: https://orcid.org/0000-0002-8078-409X)
- Byron Creese (ORCID: https://orcid.org/0000-0001-6490-6037)
- Rhian Hopkins (ORCID: https://orcid.org/0000-0001-6054-3582)
- Joshua Choma
Institutions
- University of Liverpool (GB)
- King's College London (GB)
- University of Exeter (GB)
- Brunel University of London (GB)
- University of Sheffield (GB)
Publication Details
- Journal
- The British Journal of Psychiatry
- Published
- 2025-10-09
- DOI
- https://doi.org/10.1192/bjp.2025.10419
- Citations
- 2
- Primary Topic
- Schizophrenia research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 2.94
Funders
- Wellcome Trust
- National Institute for Health and Care Research
- Department of Health and Social Care
- King's College London
- Research for Patient Benefit Programme