Clinical Staging, Histopathological Features and Treatment Outcomes in Malignant Melanoma: A 10-Year Retrospective Single-Center Study

Objectives We aimed to retrospectively evaluate the clinical stage at diagnosis, histopathological features and treatment outcomes of adult patients with malignant melanoma over a 10-year period at Van YüzüncüYıl University Hospital. Materials and Methods We reviewed 95 adult patients diagnosed between January 2010 and December 2019. Collected data included demographics, melanoma subtypes, tumor location, AJCC stage, treatment approaches and survival outcomes. Results The cohort consisted of 52.6% males and 47.4% females, with a mean age of 56.9±16.4 years. Cutaneous melanoma was the most common subtype (81.1%), with nodular melanoma as the predominant histological type. Lesion location significantly affected survival (*p*<0.05). Stage IV was the most frequent at diagnosis (43.2%). Interferon and chemotherapy were common adjuvant therapies. All ocular melanoma cases underwent surgical enucleation. The median follow-up was 24.4 months. Median overall survival was 11.3 months; the 5-year survival rate was 63.6%. Conclusion Our findings emphasize the prognostic impact of histological subtype, tumor site and disease stage at diagnosis. Expanded access to novel therapies may improve outcomes in this patient population.