Large-scale multiomic analysis identifies non-coding somatic driver mutations and nominates <i>ZFP36L2</i> as a driver gene for pancreatic ductal adenocarcinoma

Our integrative approach provides a catalogue of potential non-coding driver mutations and nominates <i>ZFP36L2</i> as a novel PDAC driver gene with a likely tumour suppressor function.

Authors

Institutions

Publication Details

Journal
Gut
Published
2025-10-08
DOI
https://doi.org/10.1136/gutjnl-2025-335152
Citations
1
Primary Topic
Pancreatic and Hepatic Oncology Research
Type
article
Field-Weighted Citation Impact
1.05

Funders

Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Large-scale multiomic analysis identifies non-coding somatic driver mutations and nominates ZFP36L2 as a driver gene for pancreatic ductal adenocarcinoma

Irene Collins, Daina Eiser, Michelle E. Leonard, Katelyn E. Connelly et al.
1 citations
Gut
Pancreatic and Hepatic Oncology Research
1.05
article

Large-scale multiomic analysis identifies non-coding somatic driver mutations and nominates ZFP36L2 as a driver gene for pancreatic ductal adenocarcinoma

Irene Collins, Daina Eiser, Michelle E. Leonard, Katelyn E. Connelly, Ashley Jermusyk, Michael Mobaraki, Li Wang, Jianxin Shi, Laufey T. Ámundadóttir, Þorkell Andrésson, Tongwu Zhang, James A. Pippin, Struan F.A. Grant, Courtney D. Dill, H. Efsun Arda, Jason W. Hoskins, Andrew Wells, Sudipto Das, Aidan O’Brien, Maura O’Neill, Thucnhi Truongvo, Konnie Guo, Minal Patel
article en
1 citations

Abstract

Our integrative approach provides a catalogue of potential non-coding driver mutations and nominates <i>ZFP36L2</i> as a novel PDAC driver gene with a likely tumour suppressor function.

GutVol. 75(3)
Leidos (United States) (US), Queen's University Belfast (GB), Children's Hospital of Philadelphia (US), National Cancer Institute (US), Division of Cancer Epidemiology and Genetics, University of Pennsylvania (US)
Government of Ontario, National Institutes of Health, National Cancer Institute, Division of Cancer Epidemiology and Genetics, National Cancer Institute
Openalex Percentile: Top 17%
Pancreatic and Hepatic Oncology Research
1.05
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.