Large-scale multiomic analysis identifies non-coding somatic driver mutations and nominates <i>ZFP36L2</i> as a driver gene for pancreatic ductal adenocarcinoma
Our integrative approach provides a catalogue of potential non-coding driver mutations and nominates <i>ZFP36L2</i> as a novel PDAC driver gene with a likely tumour suppressor function.
Authors
- Irene Collins (ORCID: https://orcid.org/0000-0001-5434-4659)
- Daina Eiser
- Michelle E. Leonard
- Katelyn E. Connelly (ORCID: https://orcid.org/0000-0002-1693-5519)
- Ashley Jermusyk (ORCID: https://orcid.org/0000-0003-1553-039X)
- Michael Mobaraki
- Li Wang (ORCID: https://orcid.org/0000-0002-9176-9194)
- Jianxin Shi (ORCID: https://orcid.org/0000-0002-7717-0863)
- Laufey T. Ámundadóttir (ORCID: https://orcid.org/0000-0003-1859-8971)
- Þorkell Andrésson (ORCID: https://orcid.org/0000-0002-9545-2450)
- Tongwu Zhang (ORCID: https://orcid.org/0000-0003-2124-2706)
- James A. Pippin (ORCID: https://orcid.org/0000-0002-6850-8164)
- Struan F.A. Grant (ORCID: https://orcid.org/0000-0003-2025-5302)
- Courtney D. Dill (ORCID: https://orcid.org/0000-0002-7293-8968)
- H. Efsun Arda (ORCID: https://orcid.org/0000-0002-5294-2521)
- Jason W. Hoskins (ORCID: https://orcid.org/0000-0001-6944-1996)
- Andrew Wells (ORCID: https://orcid.org/0000-0003-2345-9677)
- Sudipto Das (ORCID: https://orcid.org/0009-0000-8325-0088)
- Aidan O’Brien (ORCID: https://orcid.org/0000-0003-2188-4223)
- Maura O’Neill
- Thucnhi Truongvo
- Konnie Guo
- Minal Patel
Institutions
- Leidos (United States) (US)
- Queen's University Belfast (GB)
- Children's Hospital of Philadelphia (US)
- National Cancer Institute (US)
- Division of Cancer Epidemiology and Genetics
- University of Pennsylvania (US)
Publication Details
- Journal
- Gut
- Published
- 2025-10-08
- DOI
- https://doi.org/10.1136/gutjnl-2025-335152
- Citations
- 1
- Primary Topic
- Pancreatic and Hepatic Oncology Research
- Type
- article
- Field-Weighted Citation Impact
- 1.05
Funders
- Government of Ontario
- National Institutes of Health
- National Cancer Institute
- Division of Cancer Epidemiology and Genetics, National Cancer Institute