Development and evaluation of a novel prehospital antidote service providing methylthioninium chloride (methylene blue) for sodium nitrite poisoning
The limited number of cases seen in the evaluation period suggests that restricting the prehospital provision of methylthioninium chloride to specialist teams is proportionate, and it appears feasible for specialist paramedics to deliver prehospital methylthioninium chloride under PGD indications. However, prehospital use of methylthioninium chloride for the treatment of methaemoglobinaemia currently lacks sufficient evidence to support widespread adoption without further evaluation.
Authors
- Jason A. Wiles (ORCID: https://orcid.org/0000-0001-7402-6914)
- Chris Humphries (ORCID: https://orcid.org/0000-0002-6231-2603)
- Alison Walker (ORCID: https://orcid.org/0000-0002-2232-9734)
- Gregory Davies
Institutions
- Harrogate and District NHS Foundation Trust (GB)
- East Midlands Ambulance Service NHS Trust (GB)
- The Queen's Medical Research Institute (GB)
Publication Details
- Journal
- Emergency Medicine Journal
- Published
- 2025-10-08
- DOI
- https://doi.org/10.1136/emermed-2024-214777
- Primary Topic
- Poisoning and overdose treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Scottish Government
- UK Research and Innovation
- Chief Scientist Office, Scottish Government Health and Social Care Directorate
- Medical Research Council